Ray Ban Shop

Ben Ravilious photographs logo


HOME

ABOUT

GALLERY
Leicester
Singapore
Devon
Scotland
People
Animals
Nature
Miscellaneous

BUY PRINTS & IMAGES

SUGGESTIONS

CONTACT

LINKS

Replica Ray Ban Wayfarer Uk,Ray Ban Wayfarer Uk Online

 Ray Ban Sunglasses Cheap benravilious.com Ray Ban Shop

Ben Ravilious photographs logo


HOME

ABOUT

GALLERY
Leicester
Singapore
Devon
Scotland
People
Animals
Nature
Miscellaneous

BUY PRINTS & IMAGES

SUGGESTIONS

CONTACT

LINKS

Ray Ban Sunglasses Cheap

Alternative DNA vaccine constructs such as fully synthetic linear expressing cassettes (LECs) offer the advantage of accelerated manufacturing techniques as well as the lack of both antibiotic resistance genes and bacterial contaminants. The speed of manufacture makes LEC technology a possible future vaccination strategy for pandemic influenza outbreaks. Previously, we reported on a novel concept of DNA delivery to dermal tissue by a minimally invasive electroporation (EP) surface device powered using low voltage parameters. This device allows electroporation without penetration of electrodes into the skin. In addition to enhancing the delivery of traditional plasmid DNA vaccines, this device may also offer a safe, tolerable and efficient method to administer LECs. To assess immunogenicity and efficacy of EP-enhanced LEC delivery in mice, we designed and tested two influenza antigens in the form of LEC constructs delivered using the newly developed surface dermal EP device. Strong CTL and antibody responses were induced by the LEC versions of the DNA vaccine. When challenged with A/Canada/AB/RV1532/2009 viruses, mice immunized with LEC encoding the M2 and NP antigens recovered faster than naïve or mice immunized ID without EP. Mice immunized with equal-molar doses of LEC encoding the M2 and NP antigens demonstrated 100% survival following a lethal (100× LD50) challenge of the heterologuos and highly pathogenic H5N1 influenza virus (A/Vietnam/1203/04). These results suggest that influenza DNA vaccines based on LEC technology combined with the surface delivery platform are capable of fully protecting mice in a lethal challenge and the LEC based DNA constructs may serve as viable vaccine candidates.Copyright © 2012 Elsevier Ltd. All rights reserved.  

  • Ray Ban Sunglasses Sale
  • Ray Ban Knockoffs
  • Ray Bans Aviators
  • Ray Ban Wayfarers Uk Replica Ray Ban Wayfarer Uk
  • Ray Ban Glasses Uk Deals
  • Ray Ban Aviator
  • Ray Ban Outlet London
  • Ray Bans Sunglasses
  • Ray Ban Aviators Polarized Uk
  • Ray Ban Wayfarer Matte Black
  •  

    Replica Ray Ban Sunglasses,Ray Ban Aviators Cheap
    Buy Ray Ban Glasses Online,Ray Ban Aviators Women Uk
    Cheap Ray Bans For Sale,Fake Ray Bans Uk Paypal
    Ray Ban Online Store Uk,Ray Ban Stockists Cornwall
    Ray Bans Uk Shop,Fake Ray Bans Uk Ebay
    Fake Ray Bans Amazon,Ray Ban Outlet